Compositions and methods for inducing immune tolerance
US9981023B2 · kind B2 · utility
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4References
8Claims
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Assignee
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Key dates
| Filing date | Dec 6, 2016 |
| Grant date | May 29, 2018 |
| Priority date | — |
| Expiry date | Dec 6, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/55555
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides liposomal compositions for inducing immune tolerance. The compounds typically comprise a liposome displaying a specific antigen and also a binding moiety for a sialic acid binding Ig-like lectin (Siglec) expressed on B cells. The invention also provides methods for inducing tolerance to a protein or polypeptide antigen (e.g., a protein antigen) in a subject. The methods involve administering to the subject a pharmaceutical composition thatco-presents both the antigen and a glycan ligand for a Siglec expressed on B lymphocytes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.