Bicyclic ureas and thiadiazolidine-1, 1-dioxides as CETP inhibitors

US9981970B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Jian Liu · Xi'an, CN
• Pengcheng Patrick Shao · Fanwood, US
• Arto K. Krikorian · New York, US
• Petr Vachal · Summit, US

Key dates

• Filing date: Jul 28, 2014
• Grant date: May 29, 2018
• Expiry date: Aug 6, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein X is —C(═O) or —S(O)2—, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis.