Methods of treating or preventing pruritis by blocking natriuretic polypeptide B

US9987330B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Mark Hoon · Kensington, US
• Santosh K. Mishra · Rockville, US

Key dates

• Filing date: Dec 4, 2014
• Grant date: Jun 5, 2018
• Expiry date: Dec 4, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a method of treating, reducing, or preventing pruritis in a mammal, the method comprising administering at least one natriuretic polypeptide b (Nppb) blocking agent to a mammal in an amount effective to treat or prevent pruritis in the mammal. An in vitro method of identifying a compound that inhibits Nppb activity is also disclosed.