Methods for preparation of quinazoline derivatives

US9988357B2 · kind B2 · utility

Assignee

• Araxes Pharma LLC · US

Inventors

• Neelakandha S. Mani · San Diego, US
• Brett D. Allison · Del Mar, US
• Zachary S. Sales · Escondido, US
• Jimmy T. Liang · San Diego, US
• Xiaohu Deng · San Diego, US
• Liansheng Li · San Diego, US
• Yun Oliver Long · San Diego, US
• Yuan Liu · Billerica, US
• Pingda Ren · San Diego, US

Key dates

• Filing date: Dec 9, 2016
• Grant date: Jun 5, 2018
• Expiry date: Dec 9, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F3/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Methods for preparing compounds having the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b and R4c, are as defined herein are provided. Related compounds and methods for making the same are also provided.