Orthogonal ion sampling for electrospray .[.LC/MS.]. mass spectrometry

USRE36892E · kind E · reissue

Assignee

• AGILENT TECHNOLOGIES, INC. · US

Inventors

• James Apffel · Mountain View, US
• Mark H. Werlich · Santa Clara, US
• James L. Bertsch · Palo Alto, US
• Paul C. Goodley · Healdsburg, US
• Kent D. Henry · Laramie, US

Key dates

• Filing date: Jan 31, 1997
• Grant date: Oct 3, 2000
• Expiry date: Jan 31, 2017

Classification

• Technology area (CPC —): General

Abstract

.[.The invention teaches the uses of a plurality of electric fields and of orthogonal spray configurations of vaporized analyte which combine so as to operate to enhance the efficiency of analyte detection and mass analysis with a mass spectrometer by reducing vapor in the vacuum system and concomitant noise. Several embodiments of the invention are described for purposes of illustration..]. .Iadd.The invention relates to a method and apparatus for improving signal relative to noise without loss of ion collection efficiency in electrospray mass spectrometry, including liquid chromatography/mass spectrometry..Iaddend.