1-(1,2-Disubstituted piperidinyl)-4-substituted piperazine derivatives

USRE37886E1 · kind E1 · reissue

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Frans Eduard Janssens · Bonheiden, BE
• François Maria Sommen · Wortel, BE
• Dominique Louis Nestor Ghislain Surleraux · Braine-le-Comte, BE
• Joseph Elisabeth Leenaerts · Rijkevorsel, BE
• Yves Emiel Maria Van Roosbroeck · Heist-op-den-Berg, BE

Key dates

• Filing date: Aug 23, 2001
• Grant date: Oct 15, 2002
• Expiry date: Aug 23, 2021

Classification

• Technology area (CPC —): General

Abstract

This invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, as substance-P antagonists; their preparation, compositions containing them and their use as a medicine.