Styryl compounds which inhibit EGF receptor protein tyrosine kinase

USRE38761E1 · kind E1 · reissue

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Alexander Levitzki · Melrose, US
• Chaim Gilon · Jerusalem, IL
• Michael Chorev · Sharon, US
• Aviv Gazit · Jerusalem, IL

Key dates

• Filing date: Oct 14, 1994
• Grant date: Jul 19, 2005
• Expiry date: Oct 14, 2014

Classification

• Technology area (CPC —): General

Abstract

A method of inhibiting cell proliferation in a patient suffering from such disorder comprising administering to said patient an effective amount of a composition comprising, in admixture with a pharmaceutically acceptable carrier, a compound, or a pharmaceutically acceptable salt thereof, which is a substituted styrene compound which can also be a naphthalene, an indane or a benzoxazine; including nitrile and molononitrile compounds, and pharmaceutical compositions comprising, in admixture with a pharmaceutically acceptable carrier, a pharmaceutically-effective amount of such compound.