Production of fibrinogen in transgenic animals

USRE42704E1 · kind E1 · reissue

Assignee

• Pharming Intellectual Property B.V. · NL

Inventors

• Donna E. Prunkard · Seattle, US
• Donald C. Foster · Lake Forest Park, US

Key dates

• Filing date: Jan 15, 1999
• Grant date: Sep 13, 2011
• Expiry date: Jan 15, 2019

Classification

• Technology area (CPC —): General

Abstract

Materials and methods for producing fibrinogen in transgenic non-human mammals are disclosed. DNA segments encoding Aα, Bβ and γ chains of fibrinogen are introduced into the germ line of a non-human mammal, and the mammal or its female progeny produces milk containing fibrinogen expressed from the introduced DNA segments. Non-human mammalian embryos and transgenic non-human mammals carrying DNA segments encoding heterologous fibrinogen polypeptide chains are also disclosed.