Substituted nucleosides, nucleotides and analogs thereof

USRE48171E1 · kind E1 · reissue

Assignee

• Janssen BioPharma, Inc. · US

Inventors

• Guangyi Wang · Carlsbad, US
• David Bernard Smith · San Mateo, US
• Leonid Beigelman · San Mateo, US
• Jerome Deval · Pacifica, US
• Marija Prhavc · Encinitas, US

Key dates

• Filing date: Sep 13, 2018
• Grant date: Aug 25, 2020
• Expiry date: Sep 13, 2038

Classification

• Technology area (CPC —): General

Abstract

Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.