Heteroaryl pyridone and aza-pyridone compounds

USRE48239E1 · kind E1 · reissue

Assignee

• Genentech, Inc. · US

Inventors

• James John Crawford · San Francisco, US
• Daniel Fred Ortwine · San Ramon, US
• BinQing Wei · Belmont, US
• Wendy B. Young · San Mateo, US

Key dates

• Filing date: Oct 30, 2018
• Grant date: Oct 6, 2020
• Expiry date: Oct 30, 2038

Classification

• Technology area (CPC —): General

Abstract

Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X1, X2, and X3 are N, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.