Anti-CD79B antibodies and immunoconjugates and methods of use

USRE48558E1 · kind E1 · reissue

Assignee

• Genentech, Inc. · US

Inventors

• Yvonne Chen · San Mateo, US
• Mark S. Dennis · South San Francisco, US
• David Dornan · San Mateo, US
• Kristi Elkins · San Francisco, US
• Jagath Reddy Junutula · Fremont, US
• Andrew Polson · San Francisco, US
• Bing Zheng · Mountain View, US

Key dates

• Filing date: Feb 28, 2018
• Grant date: May 18, 2021
• Expiry date: Feb 28, 2038

Classification

• Technology area (CPC —): General

Abstract

The present invention is directed to compositions of matter comprising immunoconjugates comprising an anti-CD79b antibody comprising: (i) an HVR-L1 sequence of KASQSVDYEGDSFLN (SEQ ID NO: 194), (ii) an HVR-L2 sequence of AASNLES (SEQ ID NO: 195), (iii) an HVR-L3 sequence of QQSNEDPLT (SEQ ID NO: 196), (iv) an HVR-H1 sequence of GYTFSSYWIE (SEQ ID NO: 202), (v) an HVR-H2 sequence of GEILPGGGDTNYNEIFKG (SEQ ID NO: 203), and (vi) an HVR-H3 sequence of TRRVPIRLDY (SEQ ID NO: 204) and to methods of using those compositions of matter for the treatment of hematopoietic tumor in mammals.