Substituted pyrido[3,4-d]pyrimidines and pyrido[4,3-d]pyrimidines as p70S6K inhibitors

US10233160B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Bayard R. Huck · Sudbury, US
• Ruoxi Lan · Waltham, US
• Justin Potnick · Acton, US
• Lizbeth Celeste Deselm · Melrose, US
• Mark Cronin · Cambridge, US
• Constantin Neagu · Belmont, US
• Xiaoling Chen · Sharon, US
• Roch Boivin · North Chelmsford, US
• Theresa L. Johnson · Salem, US
• Andreas Goutopoulos · Boston, US

Key dates

• Filing date: Apr 24, 2018
• Grant date: Mar 19, 2019
• Expiry date: Apr 24, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel azaquinazoline carboxamide derivatives of formula (I) wherein W1, W2, W3, W4, R1, R2, R3 and m which are defined above, are p70S6K inhibitor, and can be employed, inter alia, for the treatment of hyperproliferative disorders.