Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents

US10233192B2 · kind B2 · utility

Assignees

• William Marsh Rice University · US
• THE SCRIPPS RESEARCH INSTITUTE · US
• Bristol-Myers Squibb Company · US

Inventors

• Kyriacos C. Nicolaou · Philadelphia, US
• Min Lu · San Diego, US
• Debashis Mandal · Fremont, US
• Sanjeev Gangwar · Foster City, US
• Naidu S. Chowdari · Sunnyvale, US
• Yam B. Poudel · Fremont, US

Key dates

• Filing date: Aug 15, 2017
• Grant date: Mar 19, 2019
• Expiry date: Aug 15, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.