Compositions and methods for inhibition of expression of protein C (PROC) genes

US10273478B2 · kind B2 · utility

Assignee

• Alnylam Pharmaceuticals, Inc. · US

Inventors

• Ivanka Toudjarska · Medford, US
• John M. Maraganore · Concord, US
• Brian Bettencourt · Groton, US
• Stuart Milstein · Cambridge, US
• Martin Maier · Cambridge, US
• Klaus Charisse · Acton, US
• Kallanthottathil G. Rajeev · Wayland, US
• Satyanarayana Kuchimanchi · Cambridge, US

Key dates

• Filing date: Jul 6, 2017
• Grant date: Apr 30, 2019
• Expiry date: Jul 6, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/3521
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to double-stranded ribonucleic acid (dsRNA) targeting a PROC gene, and methods of using the dsRNA to inhibit expression of PROC.