Construction of West Nile virus and dengue virus chimeras for use in a live virus vaccine to prevent disease caused by West Nile virus

US10456461B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• The Government of the United States, as represented by the Secretary of the Army · US

Inventors

• Alexander G. Pletnev · Rockville, US
• Joseph R. Putnak · Silver Spring, US
• Robert M. Chanock · Bethesda, US
• Brian R. Murphy · Bethesda, US
• Stephen S. Whitehead · Montgomery Village, US
• Joseph E. Blaney · Frederick, US

Key dates

• Filing date: Jul 2, 2018
• Grant date: Oct 29, 2019
• Expiry date: Jul 2, 2038

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.