Oligonucleotides comprising acyclic and abasic nucleosides and analogs
US10913767B2 · kind B2 · utility
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25Claims
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Assignee
Inventors
Key dates
| Filing date | Apr 22, 2011 |
| Grant date | Feb 9, 2021 |
| Priority date | — |
| Expiry date | Apr 29, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/332
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to an oligonucleotide comprising one or more abasic nucleoside monomers of formula V: These monomers are useful for modifying of oligonucleotides at one or more positions. This invention also relates to a method of inhibiting the expression of a target gene in a cell. The method comprises contacting the cell with an oligonucleotide having one or more of the above formula (V).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.