Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3- fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use

US10954234B2 · kind B2 · utility

Assignees

• Genentech, Inc. · US
• Hoffmann-La Roche Inc. · US

Inventors

• Cheol K. Chung · South San Francisco, US
• Jie Xu · Foster City, US
• Hans Iding · Rheinfelden (Baden), DE
• Kyle Bradley Pascual Clagg · San Francisco, US
• Michael E. DALZIEL · South San Francisco, US
• Alec Fettes · Basel, CH
• Francis Gosselin · South San Francisco, US
• Ngiap-Kie Lim · South San Francisco, US
• Andrew McClory · South San Francisco, US
• Haiming Zhang · Pennington, US
• Paroma Chakravarty · San Francisco, US
• Karthik Nagapudi · South San Francisco, US
• Sarah Robinson · Mississauga, CA

Key dates

• Filing date: Jun 17, 2019
• Grant date: Mar 23, 2021
• Expiry date: Jun 17, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.