Prefusion coronavirus spike proteins and their use

US10960070B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• THE SCRIPPS RESEARCH INSTITUTE · US
• TRUSTEES OF DARTMOUTH COLLEGE · US

Inventors

• Barney Graham · Rockville, US
• Jason McLellan · Austin, US
• Andrew Ward · Village of La Jolla, US
• Robert Kirchdoerfer · Village of La Jolla, US
• Christopher Cottrell · Village of La Jolla, US
• Michael Gordon Joyce · Washington, US
• Masaru Kanekiyo · Bethesda, US
• Nianshuang Wang · Austin, US
• Jesper Pallesen · Village of La Jolla, US
• Hadi M. Yassine · Doha, QA
• Hannah Turner · San Diego, US
• Kizzmekia Corbett · Wheaton, US

Key dates

• Filing date: Oct 25, 2017
• Grant date: Mar 30, 2021
• Expiry date: Oct 25, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/20071
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.