Compositions and methods for evaluating and modulating immune responses by detecting and targeting GATA3

US11180730B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• Massachusetts Institute of Technology · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Aviv Regev · Cambridge, US
• Ana Carrizosa Anderson · Boston, US
• Le Cong · Cambridge, US
• Vijay K. Kuchroo · Newton, US
• Meromit Singer · Boston, US
• Chao Wang · State College, US

Key dates

• Filing date: Apr 30, 2018
• Grant date: Nov 23, 2021
• Expiry date: Sep 5, 2038

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides markers, marker signatures and molecular targets that correlate with dysfunction of immune cells and are advantageously independent of the immune cell activation status. The present markers, marker signatures and molecular targets provide for new ways to evaluate and modulate immune responses. Specifically, GATA3 and/or FOXO1 modulation are provided for use as markers, marker signatures and molecular targets. Therapeutic methods are also provided to treat a patient in need thereof who would benefit from an increased immune response.