Inventor · Cambridge, MA, US

Le Cong

26Patents
12h-index
42Co-inventors
77Inventor score

Filing activity: Jan 19, 2012 → Jan 26, 2023

Most-cited inventions

PatentTitleAreaCited byStatus
US8993233B2 Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains Chemistry; Metallurgy 490 Active
US8871445B2 CRISPR-Cas component systems, methods and compositions for sequence manipulation Physics 448 Active
US8906616B2 Engineering of systems, methods and optimized guide compositions for sequence manipulation Physics 422 Active
US8999641B2 Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains Chemistry; Metallurgy 407 Active
US8932814B2 CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes Chemistry; Metallurgy 397 Active
US8614092B2 Nucleotide-specific recognition sequences for designer TAL effectors Chemistry; Metallurgy 79 Active
US8450107B1 Nucleotide-specific recognition sequences for designer TAL effectors Chemistry; Metallurgy 78 Active
US8507272B2 Nucleotide-specific recognition sequences for designer TAL effectors Chemistry; Metallurgy 72 Active
US8481309B2 Nucleotide-specific recognition sequences for designer TAL effectors Chemistry; Metallurgy 64 Active
US10577630B2 Delivery and use of the CRISPR-Cas systems, vectors and compositions for hepatic targeting and therapy Chemistry; Metallurgy 48 Active
US10946108B2 Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for targeting disorders and diseases using viral components Chemistry; Metallurgy 27 Active
US11332719B2 Recombinant virus and preparations thereof Chemistry; Metallurgy 14 Active
US9370551B2 Compositions and methods of treating head and neck cancer Chemistry; Metallurgy 8 Active
US9499592B2 Transcription activator-like effectors Chemistry; Metallurgy 8 Active
US11578312B2 Engineering and optimization of systems, methods, enzymes and guide scaffolds of CAS9 orthologs and variants for sequence manipulation Chemistry; Metallurgy 6 Active
US11214797B2 Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction Chemistry; Metallurgy 3 Active
US11407985B2 Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for genome editing Chemistry; Metallurgy 1 Active
US12018275B2 Delivery and use of the CRISPR-CAS systems, vectors and compositions for hepatic targeting and therapy Chemistry; Metallurgy 1 Active
US11186825B2 Compositions and methods for evaluating and modulating immune responses by detecting and targeting POU2AF1 Physics 0 Active
US11312937B2 Nucleotide-specific recognition sequences for designer TAL effectors Chemistry; Metallurgy 0 Active
US12168789B2 Engineering and optimization of systems, methods, enzymes and guide scaffolds of CAS9 orthologs and variants for sequence manipulation Chemistry; Metallurgy 0 Active
US11180730B2 Compositions and methods for evaluating and modulating immune responses by detecting and targeting GATA3 Physics 0 Active
US11434262B2 Transcription activator-like effectors Chemistry; Metallurgy 0 Active
US11036670B2 Electronic device having USB Type-C interface, control method, and readable storage Physics 0 Active
US11996168B2 Systems and methods for determining relative abundances of biomolecules Physics 0 Active

Source: USPTO / EPO open patent data. Inventor disambiguation is heuristic; counts are objective bibliographic measures.