CRISPR enzymes and systems

US11180751B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• Massachusetts Institute of Technology · US
• President and Fellows of Harvard College · US
• Rutgers, the State University of New Jersey · US
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• Skolkovo Institute of Science and Technology · RU

Inventors

• Eugene Koonin · Bethesda, US
• Feng Zhang · Cambridge, US
• Yuri I. Wolf · Bethesda, US
• Sergey Shmakov · Moscow, RU
• Konstantin Severinov · Highland Park, US
• Ekaterina Semenova · New Brunswick, US
• Leonid Minakhin · New Brunswick, US
• Kira S. Makarova · Bethesda, US
• Silvana Konermann · Menlo Park, US
• Julia Joung · Cambridge, US
• Jonathan Gootenberg · Cambridge, US
• Omar Abudayyeh · Cambridge, US

Key dates

• Filing date: Dec 14, 2017
• Grant date: Nov 23, 2021
• Expiry date: Feb 12, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/80
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.