Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
US11180813B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 11, 2018 |
| Grant date | Nov 23, 2021 |
| Priority date | — |
| Expiry date | May 11, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B30/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed are methods for determining the immunological status of the adaptive immune system of a subject by identifying and quantifying rearranged DNA (and/or subsequently transcribed RNA) sequences encoding T cell receptor (TCR) and/or immunoglobulin (IG) polypeptides, in a lymphoid DNA-containing sample from the subject. TCR and/or IG sequence diversity and sequence distribution permit immunocompetence and immune repertoire assessment and reflect the degree of T cell or B cell clonality and clonal expansion in the sample. Methods for stratifying patient populations on the basis of immunocompetence including likelihood of responding to immunotherapy are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.