Attenuated mutant dengue viruses comprising a mutation in the NS5 non-structural protein

US11318196B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Stephen S. Whitehead · Montgomery Village, US
• Brian R. Murphy · Bethesda, US
• Kathryn A. Hanley · Las Cruces, US
• Joseph E. Blaney · Frederick, US
• Ching-Juh Lai · Bethesda, US

Key dates

• Filing date: Nov 14, 2019
• Grant date: May 3, 2022
• Expiry date: Mar 31, 2040

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.