CRISPR enzymes and systems

US11421250B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• Massachusetts Institute of Technology · US
• President and Fellows of Harvard College · US
• Rutgers, the State University of New Jersey · US
• Skolkovo Institute of Science and Technology · RU
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Konstantin Severinov · Highland Park, US
• Feng Zhang · Cambridge, US
• Yuri I. Wolf · Bethesda, US
• Sergey Shmakov · Moscow, RU
• Ekaterina Semenova · New Brunswick, US
• Leonid Minakhin · New Brunswick, US
• Kira S. Makarova · Bethesda, US
• Eugene Koonin · Bethesda, US
• Silvana Konermann · Menlo Park, US
• Julia Joung · Cambridge, US
• Jonathan Gootenberg · Cambridge, US
• Omar Abudayyeh · Cambridge, US
• Eric S. Lander · Cambridge, US

Key dates

• Filing date: Dec 16, 2017
• Grant date: Aug 23, 2022
• Expiry date: Dec 16, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/22
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.