Patent · US Active

Method, device and system for the treatment of biological cryogenic samples by plasma focused ion beams

US11735404B2 · kind B2 · utility

0Cited by

2References

13Claims

0Family size

Assignee

FEI Company · US

Inventors

Alex DE MARCO · Melbourne, AU
Sergey Gorelick · Melbourne, AU
Chad Rue · Portland, US
Joseph Christian · Hillsboro, US
Kenny Mani · Beaverton, US
Steven Randolph · Portland, US
Matthias Langhorst · Hameln, DE

Key dates

Filing date	Sep 10, 2020
Grant date	Aug 22, 2023
Priority date	—
Expiry date	Sep 24, 2040

Classification

Technology area (CPC H)Electricity
CPC primaryH01J2237/31749
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention relates to a method, a device and a system for the treatment of biological frozen samples using plasma focused ion beams (FIB). The samples can then be used for mass spectrometry (MS), genomics, such as gene sequencing analysis or next generation sequencing (NGS) analysis, and proteomics. The present invention particularly relates to a method of treatment of at least one biological sample. This method is particularly used for high performance microscopy, proteomics analytics, sequencing, such as NGS etc. According to the present invention the method comprises the steps of providing at least one biological sample in frozen form. The milling treats at least one part of the sample by a plasma ion beam comprising at least one of an O+ and/or a Xe+ plasma.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.