Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors
US11980633B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Jul 29, 2021 |
| Grant date | May 14, 2024 |
| Priority date | — |
| Expiry date | Sep 21, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are methods of treating a proliferative disease in a subject by administering a DNA-damaging agent and between about 8 and about 48 hours later administering to the subject a DNA-PK inhibitor. Exemplary DNA-PK inhibitors are represented by Formula (B-I): and by pharmaceutically acceptable salts thereof, wherein R1, Q, Ring A, and Ring B are as defined herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.