Inventor · Milford, MA, US

William Markland

29Patents
20h-index
20Co-inventors
85Inventor score

Filing activity: Mar 1, 1991 → Jul 29, 2021

Most-cited inventions

PatentTitleAreaCited byStatus
US5223409A Directed evolution of novel binding proteins Chemistry; Metallurgy 2,331 Expired
US5403484A Viruses expressing chimeric binding proteins Chemistry; Metallurgy 1,087 Expired
US5571698A Directed evolution of novel binding proteins Chemistry; Metallurgy 1,003 Expired
US5837500A Directed evolution of novel binding proteins Chemistry; Metallurgy 278 Expired
US5663143A Engineered human-derived kunitz domains that inhibit human neutrophil elastase Human Necessities 86 Expired
US7208293B2 Directed evolution of novel binding proteins Chemistry; Metallurgy 67 Expired
US6423498B1 Variegated Kunitz domain peptide library and uses thereof Chemistry; Metallurgy 65 Expired
US6979538B2 Directed evolution of novel binding proteins Chemistry; Metallurgy 61 Expired
US7118879B2 Method of recovering a nucleic acid encoding a proteinaceous binding domain which binds a target material Chemistry; Metallurgy 59 Expired
US6333402A "Kallikrein-binding ""Kunitz domain"" proteins and analogues thereof" Human Necessities 51 Expired
US6057287A "Kallikrein-binding ""Kunitz domain"" proteins and analogues thereof" Physics 46 Expired
US6010880A Inhibitors of human plasmin derived from the kunitz domains Chemistry; Metallurgy 45 Expired
US6071723A Inhibitors of human plasmin derived from the Kunitz domains Chemistry; Metallurgy 41 Expired
US6103499A Inhibitors of human plasmin derived from the Kunitz domains Chemistry; Metallurgy 39 Expired
US7628983B2 Kallikrein-binding “Kunitz domain” proteins and analogues thereof Physics 23 Active
US6953674B2 Inhibitors of human plasmin derived from the kunitz domains Chemistry; Metallurgy 22 Expired
US7078383B2 ITI-D1 Kunitz domain mutants as HNE inhibitors Chemistry; Metallurgy 21 Expired
US7893007B2 Directed evolution of novel binding proteins Chemistry; Metallurgy 21 Active
US7413537B2 Directed evolution of disulfide-bonded micro-proteins Chemistry; Metallurgy 21 Expired
US7919462B2 Inhibitors of human plasmin derived from the Kunitz domains Chemistry; Metallurgy 21 Active
US8283321B2 Kallikrein-binding “Kunitz domain” proteins and analogues thereof Physics 19 Active
US7383135B1 Methods of designing inhibitors for JNK kinases Physics 4 Expired
US11110108B2 Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors Chemistry; Metallurgy 1 Active
US8002891B2 Crystallization of C-Jun N-Terminal Kinase 3 (JNK3) Physics 0 Active
US8663629B2 Kallikrein-binding “kunitz domain” proteins and analogues thereof Physics 0 Active

Source: USPTO / EPO open patent data. Inventor disambiguation is heuristic; counts are objective bibliographic measures.