Patent · US Active

Oligonucleotide-ligand conjugates and process for their preparation

US12173288B2 · kind B2 · utility

0Cited by

10References

6Claims

0Family size

Assignee

Alnylam Pharmaceuticals, Inc. · US

Inventors

Muthiah Manoharan · Carlsbad, US
Jayaprakash K. Nair · Cambridge, US
Pachamuthu Kandasamy · Cambridge, US
Shigeo Matsuda · Cambridge, US
Alexander V. Kelin · Cambridge, US
Muthusamy Jayaraman · Cambridge, US
Kallanthottathil G. Rajeev · Wayland, US

Key dates

Filing date	Oct 2, 2020
Grant date	Dec 24, 2024
Priority date	—
Expiry date	Mar 30, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2330/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.