Human immunodeficiency viruses associated with Acquired Immune Deficiency Syndrome (AIDS), a diagnostic method for AIDS and pre-AIDS, and a kit therefor

US4708818A · kind A · utility

Assignees

• INSTITUT PASTEUR · FR
• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Luc Montagnier · Le Plessis-Robinson, FR
• Jean-Claude Chermann · Marseilles, FR
• Francoise Barre-Sinoussi · Issy-les-Moulineaux, FR
• Francoise Brun-Vezinet · Paris, FR
• Christine Rouzioux · Paris, FR
• Willy Rozenbaum · Paris, FR
• Charles Dauguet · Paris, FR
• Jacqueline Gruest · L'Haÿ-les-Roses, FR
• Marie-Therese Nugeyre · Paris, FR
• Francoise Rey · Paris, FR
• Claudine Axler-Blin · Paris, FR
• Solange Chamaret · Paris, FR
• Robert C. Gallo · Bethesda, US
• Mikulas Popovic · Bethesda, US
• Mangalasseril G. Sarngadharan · Vienna, US

Key dates

• Filing date: Oct 8, 1985
• Grant date: Nov 24, 1987
• Expiry date: Oct 8, 2005

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S436/811
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS), including Lymphadenopathy Associated Virus (LAV), are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. LAV is a Human Immunodeficiency Virus (HIV). Viral extract, structural proteins and other fractions of the retrovirus immunologically recognize the sera of such patients. Immunological reaction is used to detect antibodies that specifically bind to antigenic sites of the retrovirus in samples of body fluids from patients with AIDS or risk of AIDS. A kit for in vitro assay of LAS or AIDS is provided.