Patent · US Expired

6-[[Substituted)pyrimidinyl)ethyl]- and ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis

US4868185A · kind A · utility

9Cited by

4References

8Claims

0Family size

Assignee

WARNER-LAMBERT COMPANY LLC · US

Inventors

Alexander Chucholowski · San Diego, US
Bruce D. Roth · Ann Arbor, US
Drago R. Sliskovic · Ypsilanti, US

Key dates

Filing date	Dec 10, 1987
Grant date	Sep 19, 1989
Priority date	—
Expiry date	Dec 10, 2007

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D405/06
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Certain trans-6-[[(substituted)pyrimidin-5-yl]ethyl]- and ethenyl]tetrahydro-4-hydroxypyran-2-ones and the corresponding dihydroxy ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.