Encapsulation of antineoplastic agents in liposomes
US5077056A · kind A · utility
204Cited by
20References
20Claims
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Assignee
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Key dates
| Filing date | Dec 12, 1988 |
| Grant date | Dec 31, 1991 |
| Priority date | — |
| Expiry date | Dec 12, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/829
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for encapsulating ionizable antineoplastic agents in liposomes using transmembrane potentials are provided. Trapping efficiencies approaching 100% and rapid loading are readily achieved. Dehydration protocols which allow liposomes to be conveniently used in the administration of antineoplastic agents in a clinical setting are also provided. In accordance with other aspects of the invention, transmembrane potentials are used to reduce the rate of release of ionizable drugs from liposomes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.