Patent · US Expired

4-[4- [4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-5-methyl-3H-1,2,4-triazol-3-o ne derivatives

US5254553A · kind A · utility

4Cited by

2References

10Claims

0Family size

Assignee

Janssen Pharmaceutica NA · BE

Inventors

Jan Heeres · Vosselaar, BE
Joseph H. Mostmans · Ekeren, BE
Johan R. M. Beetens · Zandhoven, BE

Key dates

Filing date	Aug 24, 1992
Grant date	Oct 19, 1993
Priority date	—
Expiry date	Aug 24, 2012

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P37/08
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

2-[2-(4-chlorophenyl)-2-(hydroxy or oxo)ethyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-5-m ethyl-3H-1,2,4-triazol-3-one having the formula ##STR1## wherein X represents C=O or CHOH, for use as 5-lipoxygenase inhibitors. Pharmaceutical compositions, processes for preparing said compounds and compositions; and a method of treating leukotriene mediated diseases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.