Saccharide intermediates in the formation of the calicheamicin and esperamicin oligosaccharides

US5384412A · kind A · utility

Assignee

• THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

• Kyriacos C. Nicolaou · Philadelphia, US
• Robert D. Groneberg · Boulder, US
• Erwin Schreiner · Wien, AT
• Wilhelm Stahl · Idstein, DE

Key dates

• Filing date: Nov 5, 1992
• Grant date: Jan 24, 1995
• Expiry date: Nov 5, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1804
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Intermediates useful in preparing the calicheamicin and esperamicin oligosaccharides, and particularly the sulfur- and O-substituted hydroxylamine-containing B ring of both oligosaccharides, are disclosed as are methods of making and using the same, including the preparation of chimeric antibiotics using the same.