Mutated thermostable nucleic acid polymerase enzyme from Thermus species Z05
US5455170A · kind A · utility
70Cited by
2References
9Claims
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Key dates
| Filing date | Aug 27, 1993 |
| Grant date | Oct 3, 1995 |
| Priority date | — |
| Expiry date | Aug 27, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/703
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A purified thermostable enzyme is derived from the eubacterium Thermus species Z05. The enzyme has DNA polymerase, activity reverse transcriptase activity, and optionally 5'.fwdarw.3' exonuclease activity. The enzyme can be native or recombinant, and may be used with primers and nucleoside triphosphates in a temperature-cycling chain reaction where at least one nucleic acid sequence is amplified in quantity from an existing sequence.
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