Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5591737A · kind A · utility
13Cited by
11References
31Claims
0Family size
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Inventors
Key dates
| Filing date | Dec 16, 1993 |
| Grant date | Jan 7, 1997 |
| Priority date | — |
| Expiry date | Dec 16, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New substituted azetidinones of the general Formula (I) which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. ##STR1## wherein R.sub.4 is (a) ##STR2## or (b) ##STR3## where R.sub.x is carboxy C.sub.1-6 alkyl, benzyloxycarbonylC.sub.1-3 alkyl, or t-butoxycarbonylC.sub.1-3 alkyl, wherein PA1 Q is a covalent bond or ##STR4## wherein R.sub.5 and R.sub.6 are each individually C.sub.1-3 alkyl or hydrogen, PA1 Y is ##STR5## or a covalent bond.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.