Gapped 2' modified oligonucleotides
US5623065A · kind A · utility
319Cited by
11References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 21, 1994 |
| Grant date | Apr 22, 1997 |
| Priority date | — |
| Expiry date | Jun 21, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3533
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Oligonucleotides and other macromolecules are provided that have increased nuclease resistance, substituent groups for increasing binding affinity to complementary strand, and subsequences of 2'-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H enzyme. Such oligonucleotides and macromolecules are useful for diagnostics and other research purposes, for modulating protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to antisense therapeutics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.