Daunomycin derivative with reduced cytotoxicity toward normal cells
US5643887A · kind A · utility
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3References
4Claims
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Key dates
| Filing date | Apr 17, 1995 |
| Grant date | Jul 1, 1997 |
| Priority date | — |
| Expiry date | Apr 17, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/252
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Chemotherapeutic agents that exhibit cytotoxicity similar to that of daunomycin against cancer cells, but exhibit lessened cytotoxicity against normal, non-transformed cells are disclosed, as are compositions, processes for making and using the same. A contemplated chemotherapeutic agent is a daunomycin derivative whose structure corresponds to structural Formula I, wherein Ar is phenyl, 1-naphthyl or 2-naphthyl ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.