Substituted azolone derivatives

US5650411A · kind A · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Jan Heeres · Vosselaar, BE
• Joseph H. Mostmans · Ekeren, BE
• Luc Alfons Leo Van der Eycken · Vosselaar, BE
• Frank Christopher Odds · Schilde, BE
• Raymond A. Stokbroekx · Beerse, BE
• Marcel Jozef Maria Van der Aa · Kasterlee, BE

Key dates

• Filing date: Jul 18, 1995
• Grant date: Jul 22, 1997
• Expiry date: Jul 18, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1804
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The use for the manufacture of a medicament for treating Helicobacter-related diseases of a compound of formula ##STR1## a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein PA1 X and Y each independently are CH or N; PA1 R.sup.1, R.sup.2 and R.sup.3 each independently are hydrogen or C.sub.1-4 alkyl; PA1 R.sup.4 and R.sup.5 each independently are hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; PA1 Z is C.dbd.O or CHOH; and PA1 Ar is phenyl optionally substituted with up to three substituents selected from hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkyloxy, halo, trifluoromethyl, triC.sub.1-4 alkylsilyloxy, nitro, amino and cyano or pyridinyl substituted with hydroxy or C.sub.1-4 alkyloxy; and PA1 --A-- is a radical of formula ##STR2##