Antisense oligonucleotide modulation of raf gene expression
US5656612A · kind A · utility
52Cited by
11References
3Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 2, 1995 |
| Grant date | Aug 12, 1997 |
| Priority date | — |
| Expiry date | Jun 2, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3517
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Oligonucleotides are provided which are targeted to nucleic acids encoding human c-raf and capable of inhibiting raf expression. The oligonucleotides may have chemical modifications at one or more positions and may be chimeric oligonucleotides. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.