Ester and carbamate derivatives of azolones

US5710156A · kind A · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Jan Heeres · Vosselaar, BE
• Joseph H. Mostmans · Ekeren, BE
• Robert Jozef Maria Hendrickx · Beerse, BE
• Louis Jozef Elisabeth Van Der Veken · Vosselaar, BE
• Raymond A. Stokbroekx · Beerse, BE
• Marcel Jozef Maria Van de Aa · Turnhout, BE

Key dates

• Filing date: Sep 20, 1996
• Grant date: Jan 20, 1998
• Expiry date: Sep 20, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention is concerned with the compounds having the formula ##STR1## the pharmaceutically acceptable acid addition salts and the stereochemically isomeric form thereof, wherein X and Y are CH or N; R.sup.1, R.sup.2 and R.sup.3 are hydrogen or C.sub.1-4 alkyl; R.sup.4 and R.sup.5 are hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R.sup.6 is C.sub.1-6 alkyl, hydroxyC.sub.1-6 alkyl, C.sub.1-4 alkyloxyC.sub.1-6 alkyl, phenyl or phenylC.sub.1-4 alkyl; Z is C.dbd.O or CHOH; and ##STR2## compositions comprising said compounds, processes for preparing the same and the use of these compounds for treating Helicobacter related diseases.