Gene associated with X linked Kallmann syndrome and diagnostic applications therefrom

US5763166A · kind A · utility

Assignees

• INSTITUT PASTEUR · FR
• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Christine Petit · Bagneux, FR
• Jean-Michel Claverie · Rockville, US
• Jacuqeline Levilliers · Les Ulis, FR
• Renaud Legouis · Strasbourg, FR
• Jean-Pierre Hardelin · Paris, FR
• Georges Lutfalla · Paris, FR

Key dates

• Filing date: Jun 30, 1994
• Grant date: Jun 9, 1998
• Expiry date: Jun 30, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to a fragment of nucleic acid characterized in that it comprises a nucleotide sequence selected from: (A) the sequence SEQ ID No. 1; (B) the sequences of one or more bases; (C) fragments of the said sequences (A) and (B); (D) sequences complementary to the said sequences (A), (B), and (C); and (E) the sequences which hybridize with the sequences (A),(B), and (C). The corresponding peptide sequences are also disclosed. A nucleic acid fragment of the invention may be used as a primer or probe, particularly in a method for diagnosing a genetic anomaly linked to the Kallmann syndrome.