Urea and thiourea derivatives of azolones
US5811426A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 8, 1997 |
| Grant date | Sep 22, 1998 |
| Priority date | — |
| Expiry date | Jan 8, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention is concerned with the compounds having the formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X is O or S; Y is CH or N; R.sup.1, R.sup.2 and R.sup.3 each independently are hydrogen or C.sub.1-4 alkyl; R.sup.4 and R.sup.5 each independently are hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R.sup.6 is C.sub.1-4 alkyl; C.sub.1-4 alkyl substituted with arylcyclohexyl; aryl or arylcarbonyl; wherein aryl is phenyl optionally substituted with one or two substituents selected from halo and C.sub.1-4 alkyl; Z is C=O or CHOH; and ##STR2## Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a medicine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.