Sulfuric acid esters of sugar alcohols

US5830920A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Alexander Chucholowski · San Diego, US
• Jurgen Fingerle · Rheinfelden (Baden), DE
• Niggi Iberg · Basel, CH
• Hans-Peter Marki · Basel, CH
• Rita Muller · Basel, CH
• Michael Pech · Hartheim, DE
• Marianne Rouge · Basel, CH
• Gerard Schmid · Kienberg, CH
• Thomas B. Tschopp · Ettingen, CH
• Hans Peter Wessel · Heitersheim, DE

Key dates

• Filing date: Apr 26, 1996
• Grant date: Nov 3, 1998
• Expiry date: Apr 26, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C305/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein n.sup.1 -n.sup.9 are each independently 0 or 1; PA1 m.sup.1 -m.sup.9 are each independently 0 or 1, but with the proviso that at least one of m.sup.1, m.sup.2 and m.sup.3, at least one of m.sup.4, m.sup.5 and m.sup.6 and, when present, at least one of m.sup.7, m.sup.8 and m.sup.9 is 1; and wherein PA1 X.sup.1 -X.sup.18 each independently is --O--, --CONR.sup.1,--NR.sup.1 CO-- or --NR.sup.1 --; PA1 R.sup.1 is hydrogen or lower alkyl; PA1 W is a benzene or s-triazine; PA1 Y.sup.1 -Y.sup.9 each independently is an aromatic ring systems; PA1 A.sup.1 -A.sup.3 each independently is a residue of a sugar alcohol devoid of the 1-hydroxy group or a derivative thereof, a residue of a sugar acid devoid of the 1-carboxy group or a derivative thereof or tris-(hydroxymethyl)-methyl; PA1 D is the di-residue of a sugar alcohol devoid of 2 hydroxy groups or a derivative thereof or the di-residue of a sugar dicarboxylic acid devoid of 2 carboxy group or a derivative thereof; PA1 Q.sup.1 -Q.sup.3 and Z.sup.1 -Z3 each independently are the di-residue of a sugar alcohol devoid of 2 hydroxy groups or a derivative thereof or the di-residue of a sugar dicarboxylic …