Nucleic acids vectors and host cells encoding and expressing heregulin 2-.alpha.
US5834229A · kind A · utility
60Cited by
9References
40Claims
0Family size
Assignee
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Key dates
| Filing date | Oct 25, 1994 |
| Grant date | Nov 10, 1998 |
| Priority date | — |
| Expiry date | Oct 25, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel 2 polypeptides with binding affinity for the p185.sup.HER2 receptor, designated heregulin 2-.alpha. and heregulin 2-.beta., have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-.alpha. has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-.alpha. useful in the production of heregulin 2-.alpha. by recombinant means. Further provided an amino acid sequence of heregulin 2-.alpha. and heregulin 2-.beta.. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.