Method of using HRG2-.alpha. to stimulate P185.sup.HeR2
US5856110A · kind A · utility
40Cited by
10References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 12, 1995 |
| Grant date | Jan 5, 1999 |
| Priority date | — |
| Expiry date | May 12, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel 2 polypeptides with binding affinity for the p185.sup.HER2 receptor, designated heregulin 2-.alpha. and heregulin 2-.beta., have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-.alpha. has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-.alpha. useful in the production of heregulin 2-.alpha. by recombinant means. Further provided an amino acid sequence of heregulin 2-.alpha. and heregulin 2-.beta.. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.