Antibodies specific for heregulin 2-.alpha.
US5859206A · kind A · utility
49Cited by
11References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 11, 1995 |
| Grant date | Jan 12, 1999 |
| Priority date | — |
| Expiry date | Apr 11, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel polypeptides with binding affinity for the p185.sup.HER2 receptor, designated heregulin 2-.alpha. and heregulin 2-.beta., have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-.alpha. has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-.alpha. useful in the production of heregulin 2-.alpha. by recombinant means. Further provided an amino acid sequence of heregulin 2-.alpha. and heregulin 2-.beta.. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.