4-hydroxy-piperodine derivatives
US5889026A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 14, 1997 |
| Grant date | Mar 30, 1999 |
| Priority date | — |
| Expiry date | Jul 14, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to compounds of the formula ##STR1## wherein x is --O--, --NH--, --CH.sub.2 --, --CH.dbd., --CO.sub.2 --, --CONH--, --CON(lower alkyl)--, --S-- and --SO.sub.2 --; PA1 R.sup.1 -R.sup.4 are, independently from each other hydrogen, halogen, hydroxy, amino, nitro, lower-alkyl-sulfonylamido, 1- or 2-imidazolyl, 1-(1,2,4-triazolyl) or acetamido; PA1 R.sup.5, R.sup.6 are, independently from each other hydrogen, lower-alkyl, hydroxy, lower alkoxy or oxo; PA1 R.sup.7 -R.sup.10 are, independently from each other hydrogen, lower-alkyl, halogen, trifluoromethyl or lower-alkoxy; PA1 n is 0 or 1; and to pharmaceutically acceptable acid addition salts thereof. Compounds of the present invention are NMDA(N-methyl-D-aspartate)-receptor subtype selective blockers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.