Gapped 2' modified oligonucleotides
US5955589A · kind A · utility
73Cited by
9References
15Claims
0Family size
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Key dates
| Filing date | Jun 6, 1995 |
| Grant date | Sep 21, 1999 |
| Priority date | — |
| Expiry date | Jun 6, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2525/125
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Oligonucleotides and other macromolecules are provided which have increased nuclease resistance, substituent groups for increasing binding affinity to complementary strand, and subsequences of 2'-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H. Such oligonucleotides and macromolecules are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.