Antisense oligonucleotide modulation of raf gene expression
US5998385A · kind A · utility
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9Claims
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Key dates
| Filing date | Apr 23, 1998 |
| Grant date | Dec 7, 1999 |
| Priority date | — |
| Expiry date | Apr 23, 2018 |
Classification
- Technology area (CPC —)General
Abstract
Oligonucleotides are provided which are targeted to nucleic acids encoding human c-raf and capable of inhibiting raf expression. The oligonucleotides contain a methoxyethoxy (2'-O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.
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