Patent · US Expired

2'-O-aminooxy-modified oligonucleotides

US6127533A · kind A · utility

129Cited by

52References

15Claims

0Family size

Assignee

Isis Pharmaceuticals, Inc. · US

Inventors

Phillip Dan Cook · Carlsbad, US
Muthiah Manoharan · Carlsbad, US
Andrew M. Kawasaki · Oceanside, US

Key dates

Filing date	Jan 30, 1998
Grant date	Oct 3, 2000
Priority date	—
Expiry date	Jan 30, 2018

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/582
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Nucleotide compositions containing aminooxy moieties are provided. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligonucleotide is modified to include an aminooxy moiety.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.